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Interestingly, they showed that these three organisms worked together to form robust digestive plaque biofilms capable of exacerbating intestinal inflammation.Īlthough the relationship between bacteria and fungi has been recognized not only in our gut, but in our body at large, this study proved for the first time that bacteria and fungi actually work together to exacerbate the inflammatory symptoms in CD. They found that family members with CD had fungal ( Candida tropicalis) and bacterial ( Serratia marcescens and Escherichia coli) imbalances in their gut's microbiome. They then defined the microbial interactions leading to microbial imbalance in the family members suffering from CD. The review centers on a first of its kind study in which researchers characterized the gut bacterial microbiota (bacteriome) and fungal community (mycobiome) in a number of families that had members with CD and healthy relatives. In order to address this issue, we have focused our efforts on studying the fungal community in the GI tract known as the mycobiome." "Unfortunately, most research has focused on studying only the bacteria while overlooking a key player, fungus. Ghannoum, PhD, of the Center for Medical Mycology, Department of Dermatology, Case Western Reserve University and, University Hospitals Cleveland Medical Center, Cleveland, OH.
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Recent advances in science have allowed us to identify the multitude of organisms inhabiting the GI tract and parse out those that play a role in IBD," explained lead author Mahmoud A. "The human gastrointestinal (GI) tract is home to trillions of microorganisms, some beneficial and others potentially harmful.